Nifedipine: Use Dose Side effects Prevention & Warnings Interaction Overdose

Use

What’s nifedipine for?

Nifedipine is a drug with a function to prevent certain types of chest pain (angina). This drug allows you to exercise more and reduce the frequency of angina attacks. Nifedipine belongs to a class of drugs known as calcium channel blockers . This drug works by relaxing the blood vessels so that blood can flow more easily. This medicine must be used regularly to be effective. This drug should not be used to treat attacks of chest pain when it occurs. Use other medicines (such as sublingual nitroglycerin) to relieve chest pain attacks as your doctor recommends. Consult your doctor and pharmacist for more information.

The elderly should discuss the risks and benefits of this drug with a doctor or pharmacist, and other alternatives to nifedipine that are more common (such as long-reaction tablets).

OTHER USES: This section contains the use of this drug which is not listed on an approved label, but may be prescribed by your health care professional. Use this medicine for the conditions listed below only if it has been prescribed by your doctor and health professional.

This drug can also be used to treat certain blood flow disorders (Raynaud’s syndrome).

The dose of nifedipine and the side effects of nifedipine will be explained further below.

How to use nifedipine?

Use this medicine by taking it according to your doctor’s advice, usually three times a day at meal time or not, as your doctor recommends. Swallow this drug in one piece, do not grind, chew, or destroy the capsule.

The dosage depends on health conditions and response to treatment.

Your doctor may increase your dose gradually. Follow the doctor’s instructions well.

Avoid grapefruit or drink grapefruit juice while using this medicine unless your doctor or pharmacist allows it. Grapefruit can increase levels of certain drugs in your bloodstream. Ask your doctor or pharmacist for more information.

Use this medication regularly to get the desired results. To help you remember to use it at the same time every day.

Let your doctor know if your condition is getting worse (for example, your chest pain is getting worse or is increasing in frequency).

How is nifedipine stored?

This drug is best stored at room temperature, away from direct light and damp places. Do not store in the bathroom. Don’t freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product packaging or ask your pharmacist. Keep all medicines out of the reach of children and pets.

Do not flush medicine in the toilet or in the sewer unless instructed. Discard this product when it has expired or if it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Dose

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of nifedipine for adults?

Dosage for Hypertension in Adults

Initial dose:
Extended release tablets: 30 to 60 mg orally once a day
The dose can be increased gradually every 7 to 14 days.

Dosage for Migraine Prophylaxis in Adults

Initial dose:
Extended release tablets: 30 mg orally once a day
Immediate release capsules: 10 mg orally 3 times a day

Dosage for Angina Pectoris Prophylaxis in adults

Initial dose:
Extended release tablets: 30 to 60 mg orally once a day
Immediate release capsules: 10 mg oral 3 times a day
Maintenance dose:
Immediate release capsules: 10 to 30 mg oral 3 to 4 times a day

Dosages for Congenital Heart Failure in Adults

Initial dose:
Procardia XL (R): 30 to 60 mg orally once daily
Adalat (R) CC: 30 mg once daily

Doses for Premature Births in Adults

The ability of tocolitis from nifedipine has been evaluated in several studies. Doses used in the study range from 10 to 20 mg every 6 to 8 hours as needed and are tolerated to delay delivery.

What is the dose of nifedipine for children?

Doses for Emergency Hypertension in Children

Children:
Immediate release capsules: 0.25 to 0.5 mg / kg / dose (maximum 10 mg / dose) repeated every 4 to 6 hours if needed
Maximum dose: 1 to 2 mg / kg / day

Doses for Hypertension in Children

Extended release tablets:
Children: 0.25 to 0.5 mg / kg / day in 1 to 2 doses; dosage must be titrated for effect.

Maximum dose: 3 mg / kg / day up to 120 mg / day (or 180 mg / day in certain places)

Dosage for Hypertrophic Cardiomyopathy In Children

Children: 0.6 to 0.9 mg / kg / 24 hours divided into 3 or 4 doses

In what dose is nifedipine available?

Tablet, ER: 30 mg, 60 mg, 90 mg

Capsule, oral: 10 mg

Side effects

What side effects can be experienced due to nifedipine?

Seek immediate emergency help if you experience any of the following signs of an allergic reaction: rash; difficulty breathing; swelling of the face, lips, tongue, or throat.

Contact your doctor immediately if you experience serious side effects such as:

  • worsening angina
  • severe constipation and cramps, severe abdominal pain or heartburn, coughing up blood
  • feeling like you want to pass out
  • feel difficulty breathing, swelling of the hands or feet
  • a fast heartbeat and a beating heart
  • numbness or tingling
  • jaundice (yellowing eyes and skin)
  • chest pain or severe feeling, pain that radiates to the arms and shoulders, nausea, sweating, feeling unwell

Less serious side effects include:

  • headache, dizziness
  • drowsiness, feeling tired
  • nausea, constipation, diarrhea, or mild stomachache
  • sleep disorders (insomnia)
  • mild rash or itching
  • joint pain, cramps in the legs
  • feel warm, tingling, or redness on your skin
  • more frequent urination

Not everyone experiences the above side effects. There may be some side effects not mentioned above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Prevention & Warnings

What should be known before using nifedipine?

Before using Nifedipine,

  • tell your doctor if you have an allergy to nifedipine, other medicines, or any composition in the nifedipine product that is prescribed. Ask your pharmacist for a list of compositions
  • tell your doctor and pharmacist what prescription and prescription drugs, vitamins, treatments and herbal products you are taking or plan to take. Make sure you mention the following medicines: acarbose (Prandase, Precose); anticoagulants (‘blood thinners’) such as warfarin (Coumadin, Jantoven); antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); beta blockers such as atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), propranolol (Inderal), and timolol (Blocadren); carbamazepine (Carbatrol, Epitol, Tegretol); cimetidine (Tagamet); digoxin (Lanoxin, Lanoxicaps); diltiazem (Cardizem); doxazosin (Cardura); erythromycin (EES, E-Mycin, Erythrocin); fentanyl (Actiq, Duragesic, Fentora, Sublimaze); flecainide (Tambocor); HIV protease inhibitors such as amprenavir (Agenerase), atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); metformin (Glucophage); nefazodone; phenobarbital (Luminal); phenytoin (Dilantin, Diphenylan Sodium); quinidine (Quinidex); quinupristin and dalfopristin (Synercid); rifampin (Rifadin, in Rifamate, in Rifater, Rimactane); rifapentine (Priftin); tacrolimus (Prograph); valproic acid (Depakene, Depakote); and verapamil (Calan, Covera, Isoptin, Verelan). Your doctor may need to change the dosage of medication or watch you for side effects nefazodone; phenobarbital (Luminal); phenytoin (Dilantin, Diphenylan Sodium); quinidine (Quinidex); quinupristin and dalfopristin (Synercid); rifampin (Rifadin, in Rifamate, in Rifater, Rimactane); rifapentine (Priftin); tacrolimus (Prograph); valproic acid (Depakene, Depakote); and verapamil (Calan, Covera, Isoptin, Verelan). Your doctor may need to change the dosage of medication or watch you for side effects nefazodone; phenobarbital (Luminal); phenytoin (Dilantin, Diphenylan Sodium); quinidine (Quinidex); quinupristin and dalfopristin (Synercid); rifampin (Rifadin, in Rifamate, in Rifater, Rimactane); rifapentine (Priftin); tacrolimus (Prograph); valproic acid (Depakene, Depakote); and verapamil (Calan, Covera, Isoptin, Verelan). Your doctor may need to change the dosage of medication or watch you for side effects
  • tell your doctor about the herbal products you are using, especially St. John’s Wort.
  • tell your doctor if you have or have had a narrowing or blockage of the digestive system or other conditions that cause slower food digestion; or heart, liver, or kidney disease. Also tell your doctor if you have experienced a myocardial infection in the past 2 weeks
  • tell your doctor if you are pregnant, plan your pregnancy, breastfeed. If you are pregnant while using nifedipine, consult your doctor
  • Consult your doctor about the safety of using nifedipine capsules if you are aged 65 years and over. The elderly are not advised to use nifedipine capsules because they are not as safe as other drugs that can be used to treat the same condition.
  • if you are operating, including dental surgery, tell your doctor or dentist that you are using nifedipine
  • Ask your doctor about the safety of using alcoholic beverages when using nifedipine. Alcohol can worsen the side effects of nifedipine.

Is nifedipine safe for pregnant and lactating women?

There is no adequate research on the risks of using this drug in pregnant or nursing women. Always consult your doctor to consider the potential benefits and risks before using this medicine. This drug is included in the category C pregnancy risk according to the US Food and Drugs Administration (FDA)

The following are references to pregnancy risk categories according to the FDA:

  •      A = No risk,
  •      B = No risk in several studies,
  •      C = Maybe risky,
  •      D = There is positive evidence of risk,
  •      X = Contraindications,
  •      N = Unknown

Nifedipine can pass through the breast and can harm the baby. Tell your doctor when you are in labor.

Interaction

What medicines might interact with nifedipine?

Drug interactions can change the way drugs work or increase your risk for serious side effects. This document does not include all drug interactions that can occur. Keep a list of the products you use (including prescription / nonprescription medicines and herbal products) and tell your doctor and pharmacist. Do not start, stop or change the dose of any medicine without your doctor’s knowledge.

Before using this medicine, tell your doctor or pharmacist about all prescription and non-prescription drugs and herbal products that you are using, specifically those containing:

Phenytoin, quinidine, tacrolimus.

Other drugs can affect the removal of nifedipine from your body, which can affect the performance of nifedipine. Examples include cimetidine , azole antifungals (such as itraconazole ), macrolide  antibiotics  (such as  erythromycin ), rifamycins (like rifabutin ), St. John’s wort, drugs used to treat seizures (such as  carbamazepine ), and others.

Check the labels of all your medicines (such as cold and cough products, diet drugs) because they can contain ingredients that can increase heart rate and worsen chest pain (including caffeine, pseudoephedrine, and phenylephrine). Ask your pharmacist about using this product safely.

Cimetidine is a non-prescription drug that is used to treat excess stomach acid, because cimetidine can interact with nifedipine, ask the pharmacist about other products that can treat excess stomach acid.

Can food or alcohol interact with nifedipine?

Certain medicines should not be used when eating or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

  • jus Grapefruit

What health conditions can interact with nifedipine?

Other health problems can affect the use of this drug. Let your doctor know if you have other health problems, specifically:

  • aortic stenosis (narrowing of the valve to the heart)
  • heavy digestive tract blockage
  • congenital heart failure
  • heart attack
  • hypotension (low blood pressure) – use with caution. Can increase serious side effects.
  • cardiogenic shock (shock caused by a heart attack) – should not be used in patients with this condition
  • galactose intolerance (hereditary disease that rarely happens)
  • Lapp lactase deficiency (rare hereditary disease) —the extended release tablet of this drug contains lactose (milk sugar), and should not be given to patients with this condition
  • kidney problem
  • liver problems (including cirrhosis) – use with caution. The effect of nifedipine can be increased due to slower drug release from the body.

Overdose

What should I do in an emergency or overdose?

In cases of emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

Symptoms of overdose can be symptoms of hypoglycemia and the following:

  • dizzy
  • fast heart rate
  • skin is red and feels warm
  • fidgety
  • nausea
  • gag
  • swelling of the hands, feet, ankles or calves
  • blurred vision
  • passed out

What should I do if I miss a dose?

If you forget one dose of this medicine, take it as soon as possible. But when it is nearing the next dose, skip the missed dose and return to the usual dosage schedule. Do not double the dose.

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